Hitori "Bocchi-chan" ("Loner") Gotōh is a lonely high school girl whose heart lies in her guitar. She does nothing every day except strum her guitar by herself at home. However, she happens one day to meet Nijika Ijichi, who is looking for a guitarist for her group named "Kessoku Band."

The anime has received widespread critical acclaim for the animation, writing, voice acting, comedy, characters, music, and exploration of social anxiety.